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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Immunotheraphy in Allergic Diseases

Author(s): Albert Roger, Maria Basagana, Aina Teniente-Serra, Nathalie Depreux, Yanina Jurgens, Clara Padro, Sira Miquel, Carolina Elduque and Eva M. Martinez-Caceres*

Volume 24 , Issue 11 , 2018

Page: [1174 - 1194] Pages: 21

DOI: 10.2174/1381612824666180116094048

Price: $65

Abstract

The prevalence of allergic diseases is increasing worldwide. It is estimated that more than 30% of the world population is now affected by one or more allergic conditions and a high proportion of this increase is in young people. The diagnosis of allergy is dependent on a history of symptoms on exposure to an allergen together with the detection of allergen-specific IgE. Accurate diagnosis of allergies opens up therapeutic options. Allergen specific immunotherapy is the only successful disease-modifying therapy for IgE-mediated allergic diseases. New therapeutic strategies have been developed or are currently under clinical trials. Besides new routes of administration, new types of allergens are being developed. The use of adjuvants may amplify the immune response towards tolerance to the antigens. In this review, we analyze different antigen-specific immunotherapies according to administration route, type of antigens and adjuvants, and we address the special case of food allergy.

Keywords: Immunotherapy, allergy, tolerance, antigens, adjuvants, IgE.


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