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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

New Technological Developments in the Clinical Imaging of Atherosclerotic Plaque

Author(s): Luigi Landini, Maria Filomena Santarelli, Alessandro Pingitore and Vincenzo Positano

Volume 9, Issue 29, 2003

Page: [2403 - 2415] Pages: 13

DOI: 10.2174/1381612033453794

Price: $65


Direct visualization of the composition of the atherosclerotic plaque during its natural history and after therapeutic intervention may be helpful in detecting lesions with high risk of acute events and in understanding progression and regression of the disease. A wide variety of invasive and non-invasive imaging techniques is available to detect clue aspects of atherosclerosis from the early stage to the clinical evidence appearance. We will firstly review the ongoing technological and clinical research on both invasive and noninvasive techniques. Afterward, we will discuss in detail the use of high-resolution, multicontrast magnetic resonance imaging for non-invasive imaging of the plaque and its characterization in terms of its various components (i.e., thickness, lipid, fibrous, calcium, or thrombus). Finally, we will describe the potential of quantitative analysis in describing of plaque constituents with improved reproducibility.

Keywords: clinical imaging, atherosclerosis, magnetic resonance imaging, quantitative analysis

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