Structure Activity Relationship of Venom Toxins Targeting Potassium Channels

Title:Structure Activity Relationship of Venom Toxins Targeting Potassium Channels

Volume: 19 Issue: 8

Author(s): Sidra Batool*, Nighat Noureen and Mohammad Amjad Kamal

Affiliation:

• Department of Biosciences, COMSATS Institute of Information Technology, Islamabad,Pakistan

Keywords: Venom toxins, potassium channels, structure scaffolds, pore blockers, kunitz type toxins, gating modifiers, disulphide bridges.

Abstract: Background: Peptide toxins are naturally occurring rich sources of highly specific bioactive compounds from venomous animals acting on various types of ion channels.

Objective: This study mainly highlights targeting of one of the largest families of ion channels i.e. potassium channels via venom toxins.

Method: Data for reported venom toxins from diverse species is gathered and analyzed at sequence and structural extent.

Results: The similarities and differences among toxins have been demonstrated along with structure activity relationship of potassium channels with these toxins.

Conclusion: This review highlights the importance of functionally important residues and structural scaffolds of venoms interacting with potassium channels.

Cite this article as:

Batool Sidra *, Noureen Nighat and Kamal Amjad Mohammad , Structure Activity Relationship of Venom Toxins Targeting Potassium Channels, Current Drug Metabolism 2018; 19 (8) . https://dx.doi.org/10.2174/1389200219666171227205009