Generic placeholder image

Current Drug Metabolism


ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

General Review Article

Structure Activity Relationship of Venom Toxins Targeting Potassium Channels

Author(s): Sidra Batool*, Nighat Noureen and Mohammad Amjad Kamal

Volume 19, Issue 8, 2018

Page: [714 - 720] Pages: 7

DOI: 10.2174/1389200219666171227205009

Price: $65


Background: Peptide toxins are naturally occurring rich sources of highly specific bioactive compounds from venomous animals acting on various types of ion channels.

Objective: This study mainly highlights targeting of one of the largest families of ion channels i.e. potassium channels via venom toxins.

Method: Data for reported venom toxins from diverse species is gathered and analyzed at sequence and structural extent.

Results: The similarities and differences among toxins have been demonstrated along with structure activity relationship of potassium channels with these toxins.

Conclusion: This review highlights the importance of functionally important residues and structural scaffolds of venoms interacting with potassium channels.

Keywords: Venom toxins, potassium channels, structure scaffolds, pore blockers, kunitz type toxins, gating modifiers, disulphide bridges.

« Previous
Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy