Abstract
Background: Peptide toxins are naturally occurring rich sources of highly specific bioactive compounds from venomous animals acting on various types of ion channels.
Objective: This study mainly highlights targeting of one of the largest families of ion channels i.e. potassium channels via venom toxins.
Method: Data for reported venom toxins from diverse species is gathered and analyzed at sequence and structural extent.
Results: The similarities and differences among toxins have been demonstrated along with structure activity relationship of potassium channels with these toxins.
Conclusion: This review highlights the importance of functionally important residues and structural scaffolds of venoms interacting with potassium channels.
Keywords: Venom toxins, potassium channels, structure scaffolds, pore blockers, kunitz type toxins, gating modifiers, disulphide bridges.
Current Drug Metabolism
Title:Structure Activity Relationship of Venom Toxins Targeting Potassium Channels
Volume: 19 Issue: 8
Author(s): Sidra Batool*, Nighat Noureen and Mohammad Amjad Kamal
Affiliation:
- Department of Biosciences, COMSATS Institute of Information Technology, Islamabad,Pakistan
Keywords: Venom toxins, potassium channels, structure scaffolds, pore blockers, kunitz type toxins, gating modifiers, disulphide bridges.
Abstract: Background: Peptide toxins are naturally occurring rich sources of highly specific bioactive compounds from venomous animals acting on various types of ion channels.
Objective: This study mainly highlights targeting of one of the largest families of ion channels i.e. potassium channels via venom toxins.
Method: Data for reported venom toxins from diverse species is gathered and analyzed at sequence and structural extent.
Results: The similarities and differences among toxins have been demonstrated along with structure activity relationship of potassium channels with these toxins.
Conclusion: This review highlights the importance of functionally important residues and structural scaffolds of venoms interacting with potassium channels.
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Cite this article as:
Batool Sidra *, Noureen Nighat and Kamal Amjad Mohammad , Structure Activity Relationship of Venom Toxins Targeting Potassium Channels, Current Drug Metabolism 2018; 19 (8) . https://dx.doi.org/10.2174/1389200219666171227205009
DOI https://dx.doi.org/10.2174/1389200219666171227205009 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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