The Formation of 2-Isoxazolines in the Reactions of α,β-Unsaturated Carbonyl Compounds with Hydroxylamine and its Derivatives-A Critical Review

Title:The Formation of 2-Isoxazolines in the Reactions of α,β-Unsaturated Carbonyl Compounds with Hydroxylamine and its Derivatives-A Critical Review

Volume: 22 Issue: 4

Author(s): Olga Kinga Drosik*Jerzy Wiktor Suwinski

Affiliation:

• Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Gliwice,Poland

Keywords: Enal, enone, hydroxylamine, isoxazole, isoxazoline, isoxazolidine, oxime.

Abstract: Background: For more than one hundred years, it has been known that some 2- isoxazolines can be experimentally obtained by the addition of hydroxylamine or its derivatives to α,β-unsaturated carbonyl compounds.

Methodology: General methods for the formation of 2-isoxazolines have not been formulated yet.

Conclusion: This review will attempt to summarize the numerous published experimental facts on the addition of hydroxylamine or its derivatives to unsaturated carbonyl compounds and analyze these facts in the hope of proposing reaction pathways compatible with the all the experimental data.

Cite this article as:

Drosik Kinga Olga *, Suwinski Wiktor Jerzy, The Formation of 2-Isoxazolines in the Reactions of α,β-Unsaturated Carbonyl Compounds with Hydroxylamine and its Derivatives-A Critical Review, Current Organic Chemistry 2018; 22 (4) . https://dx.doi.org/10.2174/1385272822666171222143456