Abstract
In the search for synthetic routes for the preparation of cis- and trans- decahydroquinolin-2- ones, a procedure for the generation of enantiopure trans-hydrochromene lactones, by treatment of (R)- phenylglycinol-derived oxazoloquinolone lactams with Na/liq. NH3 followed by acidification, has been developed.
Keywords: Decahydroquinoline, debenzylation, lactams, lactones, perhydrochromene, sodium-ammonia.
Graphical Abstract
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