摘要
背景:从过去十年到现在,有关脑瘤中O-(2-[18F]氟乙基)-L-酪氨酸(18F-FET)正电子发射断层扫描(PET)的研究已在文献中发表。aure[地名] [法国] 欧尔河 目的:根据近期文献资料,综述18F-FETPET在脑肿瘤中的最新进展和作用。 方法:介绍近期发表的有关18F-FETPET在神经肿瘤学中的作用的主要研究成果。 结果:18F-FETPET可用于脑肿瘤与非肿瘤性病变及低、高级别胶质瘤的鉴别诊断。18F-FETPET在外科手术中的应用计划允许更好地划定切除范围以外的边缘可见标准MRI。在活检计划方面,18F-fET PET对于鉴别NO内的恶性病灶特别有用。增强对比的胶质瘤。18F-FETPET可改善胶质瘤放射治疗计划。这种代谢显像方法可用于评价脑卒中患者的治疗反应。它提高了对脑肿瘤复发和治疗后变化的鉴别诊断。18F-FETPET可为高级别胶质瘤提供有用的预后信息。 结论:根据近期文献资料,18F-FET PET可提供比标准MRI更多的神经肿瘤学诊断信息。
关键词: PET,O-(2-[18F]氟乙基)-L-酪氨酸,FET,神经肿瘤学,神经影像学,胶质瘤,脑肿瘤,胶质母细胞瘤。
Current Medicinal Chemistry
Title:Recent Developments of 18F-FET PET in Neuro-oncology
Volume: 25 Issue: 26
关键词: PET,O-(2-[18F]氟乙基)-L-酪氨酸,FET,神经肿瘤学,神经影像学,胶质瘤,脑肿瘤,胶质母细胞瘤。
摘要: Background: From the past decade to date, several studies related to O-(2- [18F]fluoroethyl)-L-tyrosine (18F-FET) positron emission tomography (PET) in brain tumours have been published in the literature.
Objective: The aim of this narrative review is to summarize the recent developments and the current role of 18F-FET PET in brain tumours according to recent literature data.
Methods: Main findings from selected recently published and relevant articles on the role of 18F-FET PET in neuro-oncology are described.
Results: 18F-FET PET may be useful in the differential diagnosis between brain tumours and non-neoplastic lesions and between low-grade and high-grade gliomas. Integration of 18F-FET PET into surgical planning allows better delineation of the extent of resection beyond margins visible with standard MRI. For biopsy planning, 18F-FET PET is particularly useful in identifying malignant foci within non-contrast-enhancing gliomas. 18F-FET PET may improve the radiation therapy planning in patients with gliomas. This metabolic imaging method may be useful to evaluate treatment response in patients with gliomas and it improves the differential diagnosis between brain tumours recurrence and posttreatment changes. 18F-FET PET may provide useful prognostic information in high-grade gliomas.
Conclusion: Based on recent literature data 18F-FET PET may provide additional diagnostic information compared to standard MRI in neuro-oncology.
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Cite this article as:
Recent Developments of 18F-FET PET in Neuro-oncology, Current Medicinal Chemistry 2018; 25 (26) . https://dx.doi.org/10.2174/0929867325666171123202644
DOI https://dx.doi.org/10.2174/0929867325666171123202644 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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