Advances in High-Throughput Screening: Biomolecular Interaction Monitoring in Real-Time with Colloidal Metal Nanoparticles

Title: Advances in High-Throughput Screening: Biomolecular Interaction Monitoring in Real-Time with Colloidal Metal Nanoparticles

Volume: 6 Issue: 8

Author(s): P. Englebienne, A. Van Hoonacker, M. Verhas and N. G. Khlebtsov

Affiliation:

Keywords: colloidal gold, colloidal silver, localized surface plasmon resonance, biomolecular interaction, protein conformation, affinity, real-time association, label-free detection

Abstract: The post-genomic era is revolutionizing the drug discovery process. The new challenges in the identification of therapeutic targets require efficient technological tools in order to be properly addressed. Label-free detection systems use proteins or ligands coupled to materials of which the physical properties are measurably modified upon specific interactions. Among the label-free systems currently available, the use of metal nanocolloids offers enhanced throughput and flexibility for real-time biomolecular recognition monitoring at a reasonable cost.

Cite this article as:

Englebienne P., Hoonacker Van A., Verhas M. and Khlebtsov G. N., Advances in High-Throughput Screening: Biomolecular Interaction Monitoring in Real-Time with Colloidal Metal Nanoparticles, Combinatorial Chemistry & High Throughput Screening 2003; 6 (8) . https://dx.doi.org/10.2174/138620703771826955