Abstract
An archaic surgical procedure, the skull trepanning, was introduced in ancient Greece to treat brain derangement, and endured until the 18th century with the same use. Hippocrates recognized epilepsy as a common entity and categorized it as a brain disorder, removing any divine origin. He proposed that the excess of black bile and mucus is due to the infiltration of air inside the blood circulation (veins). For him it was a hereditary disease that could be cured. Thus, he suggested a non-invasive treatment based on herbal potions, and a surgical treatment by using the most advanced operation of the era, the open brain drilling, known as trepanning, or trephination, setting the beginning of neurosurgery.
Keywords: Hippocrates, Corpus Hippocraticum, epilepsy, trepanning, neurosurgery, herbal medicine, ancient Greece.
Current Pharmaceutical Design
Title:Epilepsy, Theories and Treatment Inside Corpus Hippocraticum
Volume: 23 Issue: 42
Author(s): Gregory Tsoucalas*, Konstantinos Spengos, George Panayiotakopoulos, Theodoros Papaioannou and Marianna Karamanou
Affiliation:
- Hellenic Reference Center for Alzheimer Disease and Related Syndromes, Alykes, Volos,Greece
Keywords: Hippocrates, Corpus Hippocraticum, epilepsy, trepanning, neurosurgery, herbal medicine, ancient Greece.
Abstract: An archaic surgical procedure, the skull trepanning, was introduced in ancient Greece to treat brain derangement, and endured until the 18th century with the same use. Hippocrates recognized epilepsy as a common entity and categorized it as a brain disorder, removing any divine origin. He proposed that the excess of black bile and mucus is due to the infiltration of air inside the blood circulation (veins). For him it was a hereditary disease that could be cured. Thus, he suggested a non-invasive treatment based on herbal potions, and a surgical treatment by using the most advanced operation of the era, the open brain drilling, known as trepanning, or trephination, setting the beginning of neurosurgery.
Export Options
About this article
Cite this article as:
Tsoucalas Gregory *, Spengos Konstantinos , Panayiotakopoulos George , Papaioannou Theodoros and Karamanou Marianna , Epilepsy, Theories and Treatment Inside Corpus Hippocraticum, Current Pharmaceutical Design 2017; 23 (42) . https://dx.doi.org/10.2174/1381612823666171024153144
| DOI https://dx.doi.org/10.2174/1381612823666171024153144 |
Print ISSN 1381-6128 |
| Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
Advances in the Molecular Pathogenesis of Inflammatory Bowel Disease.
This thematic issue will emphasize the recent breakthroughs in the mechanisms of Inflammatory bowel disease (IBD) pathogenesis and devotes some understanding of both Crohn’s and ulcerative colitis. It is expected to include studies about cellular and genetic aspects, which help to precipitate the disease, and the immune system-gut microbiome relations ...read more
Blood-based biomarkers in large-scale screening for neurodegenerative diseases
Disease biomarkers are necessary tools that can be employ in several clinical context of use (COU), ranging from the (early) diagnosis, prognosis, prediction, to monitor of disease state and/or drug efficacy. Regarding neurodegenerative diseases, in particular Alzheimer’s disease (AD), a battery of well-validated biomarkers are available, such as cerebrospinal fluid ...read more
Diabetes mellitus: advances in diagnosis and treatment driving by precision medicine
Diabetes mellitus (DM) is a chronic degenerative metabolic disease with ever increasing prevalence worldwide which is now an epidemic disease affecting 500 million people worldwide. Insufficient insulin secretion from pancreatic β cells unable to maintain blood glucose homeostasis is the main feature of this disease. Multifactorial and complex nature of ...read more
Food-derived bioactive peptides against chronic diseases
Chronic diseases, such as cardiovascular diseases and metabolic diseases, have become a great threat to the human health in recent decades due to the excessive food consumption and the prevalence of sedentary lifestyle. As a class of natural compounds, food-derived bioactive peptides have been demonstrated to possess great potential for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Histone Acetylation in Neurodevelopment
Current Pharmaceutical Design Aldehyde Dehydrogenases as Promising Targets for Treating Toxic Aldehyde-related Diseases
Current Medicinal Chemistry Routine Collection of Patient-Reported Outcomes in an HIV Clinic Setting:The First 100 Patients
Current HIV Research Lipid Nanocarriers for Neurotherapeutics: Introduction, Challenges, Blood-brain Barrier, and Promises of Delivery Approaches
CNS & Neurological Disorders - Drug Targets Anti-seizure Medications: Challenges and Opportunities
CNS & Neurological Disorders - Drug Targets Preface [Hot Topic: New Clinical Applications for Naturally Occurring Peptide Toxins (Guest Editors: Robert Jones / Graeme Semple)]
Current Medicinal Chemistry Utilizing Delta Opioid Receptors and Peptides for Cytoprotection: Implications in Stroke and Other Neurological Disorders
CNS & Neurological Disorders - Drug Targets Adult Hippocampal Neurogenesis as Target for the Treatment of Depression
CNS & Neurological Disorders - Drug Targets Editorial [Hot Topic: When Can a Drug be Declared “Safe”? (Guest Editors: Frank M.C. Besag & Seetal Dodd)]
Current Drug Safety An Update of the Classical and Novel Methods Used for Measuring Fast Neurotransmitters During Normal and Brain Altered Function
Current Neuropharmacology Updates on the Synthetic Strategies and Structure-Activity Relationship of Anticonvulsant Benzothiazole and Benzimidazole Derivatives
Letters in Drug Design & Discovery Insight into the Mechanism of the Four-Plate Test-Retest Procedure Using Etifoxine as Compared with Gabapentin
Current Psychopharmacology Peripheral Oxidative Stress Markers in Patients with Bipolar Disorder during Euthymia and in Siblings
Endocrine, Metabolic & Immune Disorders - Drug Targets Connexin Modulators and Their Potential Targets under the Magnifying Glass
Current Medicinal Chemistry Applications of Nuclear Technique to Biological Sciences Labelled Compounds, Radioactive Tracers, and X-Ray Tomography
Current Topics in Medicinal Chemistry Recent Patents, Regulatory Issues, and Toxicity of Nanoparticles in Neuronal Disorders
Current Drug Metabolism Augmentation of Citalopram with Aspirin for Treating Major Depressive Disorder, a Double Blind Randomized Placebo Controlled Clinical Trial
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Neuroinflamm-Aging and Neurodegenerative Diseases: An Overview
CNS & Neurological Disorders - Drug Targets Is Adult Hippocampal Neurogenesis Really Relevant for the Treatment of Psychiatric Disorders?
Current Neuropharmacology HCN Channels Modulators: The Need for Selectivity
Current Topics in Medicinal Chemistry

