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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Tumor Escape from Immune Response: Mechanisms and Targets of Activity

Author(s): Dmitry Gabrilovich and Vladimir Pisarev

Volume 4, Issue 7, 2003

Page: [525 - 536] Pages: 12

DOI: 10.2174/1389450033490849

Price: $65


Immune system plays an important role in control of tumor progression. Effective antitumor immune response depends on close interaction of several elements of immune system. They include antigen-presenting cells, different subsets of T cells, B cells and NK cells. However, tumor cells developed a number of mechanisms to escape recognition and elimination by immune system. In this review we will discuss these mechanisms and address possible approaches to correct them.

Keywords: Immune, tumor cells, antigen-presenting cells

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