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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Potential of Plant-sourced Phenols for Inflammatory Bowel Disease

Author(s): Hai-tao Xiao, Bo Wen, Xiang-chun Shen* and Zhao-xiang Bian*

Volume 25 , Issue 38 , 2018

Page: [5191 - 5217] Pages: 27

DOI: 10.2174/0929867324666171009100900

Price: $65


Inflammatory bowel disease (IBD) is an uncontrolled chronic inflammatory intestinal disorder, which requires medications for long-term therapy. Facing the challenges of severe side effects and drug resistance of conventional medications, to develop the strategies meet the stringent safety and effectiveness in the long-term treatment are urgent in the clinics. In this regard, a growing body of evidence confirms plant-sourced phenols, such as flavonoids, catechins, stilbenes, coumarins, quinones, lignans, phenylethanoids, cannabinoid phenols, tannins, phenolic acids and hydroxyphenols, exert potent protective benefits with fewer undesirable effects in conditions of acute or chronic intestinal inflammation through improvement of colonic oxidative and pro-inflammatory status, preservation of the epithelial barrier function and modulation of gut microbiota. In this review, the great potential of plant-sourced phenols and their action mechanisms for the treatment or prevention of IBD in recent research are summarized, which may help further development of new preventive/adjuvant regimens for IBD.

Keywords: Inflammatory bowel disease, plant-sourced phenols, therapeutic effects, action mechanism, ulcerative colitis, Crohn's disease, colonic tissue edema.

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