Abstract
Background: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.
Methods: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.
Results: However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent. Second, the particle growth needs to be adjusted by surfactant addition.
Conclusion: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed.
Keywords: Nanoprecipitation, poorly water-soluble drug, solvent removal technique, surfactant, anti-solvent, nanoparticulate.
Graphical Abstract
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
Tissue Distribution and Metabolism of Micro- and Nanoparticles and Medical Implants
With the continuous advancement of modern science and engineering, numerous functional materials and active molecules have been developed and utilized in various industrial, medical, and food applications. Many of these can enter the body, either actively or passively, and have significant and intricate impacts on human health. For example, biomaterials ...read more
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