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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Fluorescence Polarization Assays in Signal Transduction Discovery

Author(s): J. Richard Sportsman, Janet Daijo and Elizabeth A. Gaudet

Volume 6, Issue 3, 2003

Page: [195 - 200] Pages: 6

DOI: 10.2174/138620703106298374

Price: $65


Fluorescence polarization (FP) has become widely employed for high throughput screening used in pharmaceutical drug discovery. Assays of important signal transduction targets are now adapted to FP. In this review we examine assays for cyclic adenosine monophosphate, phosphodiesterases, and protein kinases and phosphatases using FP competitive immunoassays and a direct enzymatic method called IMAP.

Keywords: Fluorescence Polarization, adenosine monophosphate, phosphodiesterases

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