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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Seven-membered Rings with Three Heteroatoms: Chemistry of 1,2,5- and 1,4,5- thiadiazepines

Author(s): Basak Dogru Mert* and Khaled M. Elattar

Volume 22, Issue 4, 2018

Page: [386 - 410] Pages: 25

DOI: 10.2174/1385272821666170920163512

Price: $65


This review describes the chemistry of 1,2,5- and 1,4,5-thiadiazepines. The investigated heterocycles are monocyclic and fused 1,2,5- and 1,4,5-thiadiazepines. The different sections cover: structural elucidation "spectroscopy", reactivity of substituents attached to ring carbon and nitrogen atoms, synthesis of monocyclic and fused heterocycles incorporated 1,2,5- and 1,4,5-thiadiazepine moiety. Nitrogen and sulfur atoms of thiadiazepine ring system have the ability to donate the electrons pairs in order to form coordination bonds forming different complexes. The aim of this review is to discuss the chemistry of title compounds up till now. The reaction mechanisms are described and discussed, as well as, the biological applications of the target compounds.

Keywords: 1, 2, 5-Thiadiazepines, 1, 4, 5-thiadiazepines, spectroscopic data, reactivity, synthetic methods, biological importance.

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