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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Cysteine-rich Proteins for Drug Delivery and Diagnosis

Author(s): Guang Yang*, Yue Lu, Hunter N. Bomba and Zhen Gu*

Volume 26, Issue 8, 2019

Page: [1377 - 1388] Pages: 12

DOI: 10.2174/0929867324666170920163156

Price: $65


An emerging focus in nanomedicine is the exploration of multifunctional nanocomposite materials that integrate stimuli-responsive, therapeutic, and/or diagnostic functions. In this effort, cysteine-rich proteins have drawn considerable attention as a versatile platform due to their good biodegradability, biocompatibility, and ease of chemical modification. This review surveys cysteine-rich protein-based biomedical materials, including protein-metal nanohybrids, gold nanoparticle-protein agglomerates, protein-based nanoparticles, and hydrogels, with an emphasis on their preparation methods, especially those based on the cysteine residue-related reactions. Their applications in tumor-targeted drug delivery and diagnostics are highlighted.

Keywords: Cysteine-rich protein, drug delivery, cancer diagnostics, protein-based nanoparticle, hydrogel, biomedical material.

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