Cyclophosphamide and/or Anthracyclines Induced Epiphora in Breast Cancer Patients: A Rare Side-effect

Title:Cyclophosphamide and/or Anthracyclines Induced Epiphora in Breast Cancer Patients: A Rare Side-effect

Volume: 13 Issue: 1

Author(s): Ruchika Kalra, Bhavesh Chavada, Nishant R. Madhani, Bhargav Purohit*C.B. Tripathi

Affiliation:

• Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat),India

Keywords: Cyclophosphamide, anthracyclines, epiphora, chemotherapy, ophthalmic examination, ocular adverse effects.

Abstract: Background: Two female breast cancer patients developed epiphora after administration of cyclophosphamide and/or anthracyclines based 2-day chemotherapy regimen. An ophthalmologist was consulted and no apparent cause was found.

Case Description: Patients were managed by ciprofloxacin eye drops. Chemotherapy induced ocular complications are not uncommon, but under reported. Although epiphora is a mild reaction, if severe however, it can interfere with daily activities. Patients having chemotherapy induced ocular toxicity should go for ophthalmic examination to pick up ocular adverse effects of anticancer drugs and treat them at an early stage.

Cite this article as:

Kalra Ruchika , Chavada Bhavesh, Madhani R. Nishant, Purohit Bhargav*, Tripathi C.B., Cyclophosphamide and/or Anthracyclines Induced Epiphora in Breast Cancer Patients: A Rare Side-effect, Current Drug Safety 2018; 13 (1) . https://dx.doi.org/10.2174/1574886312666170919175614