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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Review Article

Glycan Phosphorylases in Multi-Enzyme Synthetic Processes

Author(s): Giulia Pergolizzi, Sakonwan Kuhaudomlarp, Eeshan Kalita and Robert A. Field*

Volume 24, Issue 8, 2017

Page: [696 - 709] Pages: 14

DOI: 10.2174/0929866524666170811125109

open access plus


Glycoside phosphorylases catalyse the reversible synthesis of glycosidic bonds by glycosylation with concomitant release of inorganic phosphate. The equilibrium position of such reactions can render them of limited synthetic utility, unless coupled with a secondary enzymatic step where the reaction lies heavily in favour of product. This article surveys recent works on the combined use of glycan phosphorylases with other enzymes to achieve synthetically useful processes.

Keywords: Phosphorylase, disaccharide, α-glucan, cellodextrin, high-value products, biofuel.

Graphical Abstract

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