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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Recent Progress in Biological Activities of Indole and Indole Alkaloids

Author(s): Thokchom Prasanta Singh and Okram Mukherjee Singh*

Volume 18, Issue 1, 2018

Page: [9 - 25] Pages: 17

DOI: 10.2174/1389557517666170807123201

Price: $65


The indole scaffold is found in a wide range of bioactive heterocycles and natural products. Moreover, the indole moiety is considered as the active principle in several alkaloids such as mitomycin C and reserpine. Thus, over the past decade, chemists are increasingly attracted towards the studies on the pharmacological and therapeutic activities of indole containing compounds. Furthermore, the molecular structures of well-known drugs such as sumatriptan, tadalafil, fluvastatin and rizatriptan are based on indole frameworks.

This mini-review covers some of the significant and recent achievements of indole derivatives with respect to their biological activities up to 2015.

Keywords: Anti-cancer, anti-HIV, anti-microbial, anti-oxidant, biological activities, indole.

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