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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Sarcopenia, Aging and Prospective Interventional Strategies

Author(s): Tyler B. Waltz, Elayne M. Fivenson, Marya Morevati, Chuanhao Li, Kevin G. Becker, Vilhelm A. Bohr and Evandro F. Fang*

Volume 25 , Issue 40 , 2018

Page: [5588 - 5596] Pages: 9

DOI: 10.2174/0929867324666170801095850

Price: $65

Abstract

Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.

Keywords: Sarcopenia, aging, mitochondria, mitophagy, phytochemical, nicotinamide adenine dinucleotide.


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