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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Review Article

The Angiotensin Converting Enzyme 2 (ACE2), Gut Microbiota, and Cardiovascular Health

Author(s): Joao Marcus Oliveira Andrade*, Deborah de Farias Lelis, Valeria Mafra and Junio Cota

Volume 24, Issue 9, 2017

Page: [827 - 832] Pages: 6

DOI: 10.2174/0929866524666170728145333

Price: $65


Background: The renin-angiotensin system (RAS) is an important enzymatic system responsible for the regulation of biological functions, such as the arterial pressure, hydroelectrolytic control, vascular vasodilatation/vasoconstriction and more recently metabolic functions.

Objectives: The aim of the present review is to discuss the associations between the gut microbiome and the renin-angiotensin system and the influence of their intimate relationship on the cardiovascular health.

Methods: A literature review of the main studies published regarding the relationship among the renin-angiotensin system, gut microbiota and cardiovascular health was performed.

Results: The association between the ACE2 and gut microbiota has been discussed. It is shown that the ACE2/Ang 1-7 axis modulates the immune response, influencing the microbiota composition, and thus being one of the causes for some diseases physiophatologies, such as diarrhea and intestinal inflammatory disease.

Conclusion: The association between RAS and gut microbiota seems to have a strong influence on the genesis of cardiovascular diseases, through direct mechanisms, such as nerve stimulation, or indirectly on metabolic parameters, such as weight, adiposity and lipid profile.

Keywords: Renin-angiotensin system, Angiotensin converting enzyme 2, gut microbiota, cardiovascular health, biological functions, immune response.

Graphical Abstract

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