Abstract
Borna Disease Virus (BDV) is a neurotropic RNA virus worldwide in distribution that causes movement, behavior or cognitive disorders in animal species. Borna Disease the illness ranges from asymptomatic to fatal meningoencephalitis across naturally infected warmblooded (mammalian and bird) species. There are also reported associations of the virus with neuropsychiatric diseases of man. Development of experimentally infected rodents, frequently rats, as models for examining behavioral, pharmacologic and biochemical responses to viral challenge at different stages of life have contributed to understanding the role of CNS viral injury in vulnerability to neurodevelopmental, behavioral and degenerative diseases.
Keywords: borna disease, virus, encephalitis, dopamine, serotonin, rat
Current Neuropharmacology
Title: Borna Disease Virus (BDV): Neuropharmacological Effects of a CNS Viral Infection
Volume: 1 Issue: 4
Author(s): Marylou V. Solbrig and George F. Koob
Affiliation:
Keywords: borna disease, virus, encephalitis, dopamine, serotonin, rat
Abstract: Borna Disease Virus (BDV) is a neurotropic RNA virus worldwide in distribution that causes movement, behavior or cognitive disorders in animal species. Borna Disease the illness ranges from asymptomatic to fatal meningoencephalitis across naturally infected warmblooded (mammalian and bird) species. There are also reported associations of the virus with neuropsychiatric diseases of man. Development of experimentally infected rodents, frequently rats, as models for examining behavioral, pharmacologic and biochemical responses to viral challenge at different stages of life have contributed to understanding the role of CNS viral injury in vulnerability to neurodevelopmental, behavioral and degenerative diseases.
Export Options
About this article
Cite this article as:
Solbrig V. Marylou and Koob F. George, Borna Disease Virus (BDV): Neuropharmacological Effects of a CNS Viral Infection, Current Neuropharmacology 2003; 1 (4) . https://dx.doi.org/10.2174/1570159033477035
DOI https://dx.doi.org/10.2174/1570159033477035 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
Call for Papers in Thematic Issues
Advances in Neuroinflammation and Neuroprotection: Mechanisms and Therapeutic Frontiers
It offers a comprehensive exploration of neuroinflammatory and neuroprotective pathways that play central roles in a range of neurological disorders, including stroke, traumatic brain injury, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This issue invites research on the cellular and molecular mechanisms driving neuroinflammation, such as the roles of ...read more
Advances in paediatric and adult brain cancers: emerging targets and treatments
Brain tumors are the most common solid tumors affecting children and adolescents, with up to 5,000 children diagnosed per year. Pediatric brain tumors, because of their location, are often untreatable and their clinical management can cause significant long-term impairment to intellectual and neurological function with epilepsy and neurodegeneration. Other than ...read more
Emotion (Dys)regulation: An integration of Pharmacological, Neurobiological, and Psychological Frameworks
Emotion regulation is a critical aspect of mental well-being and interpersonal relationships. To fully understand and effectively address emotion regulation, an integrative approach that considers pharmacological, neurobiological, and psychological frameworks is essential. Pharmacological interventions, such as medications targeting neurotransmitter imbalances, can play a significant role in managing emotional dysregulation. Understanding ...read more
Intercellular Communications in Cerebral Ischemia
Cerebral ischemia, a condition in which there is inadequate blood supply to the brain, ranks as one of the leading causes of disability and mortality globally. Despite its prevalence and severity, efficacious treatment options for this debilitating disorder remain limited. Recent scientific explorations have delved deeply into the pathological mechanisms ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis
Current Medicinal Chemistry Anti-Inflammatory Drugs in Psychiatry
Inflammation & Allergy - Drug Targets (Discontinued) Human Anthrax as a Re-Emerging Disease
Recent Patents on Anti-Infective Drug Discovery An Inducible Expression System for Recombinant Sca Proteins with an Autotransporter Domain from <i>Orientia Tsutsugamushi in Escherichia coli</i>
Protein & Peptide Letters Porphyrin Photosensitised Processes in the Prevention and Treatment of Water- and Vector-Borne Diseases
Current Medicinal Chemistry Virus-Associated Vasculitides
Current Immunology Reviews (Discontinued) Peripheral Immunity, Immunoaging and Neuroinflammation in Parkinson’s Disease
Current Medicinal Chemistry Applied Proteomics in Companion Animal Medicine
Current Proteomics Potential Relevance of Melatonin Against Some Infectious Agents: A Review and Assessment of Recent Research
Current Medicinal Chemistry Amyloid-Targeted Metal Chelation, Anti-Oxidative Stress, and Anti- Inflammation as Potential Alzheimers Therapies
Current Bioactive Compounds The Intracellular Domain of Amyloid Precursor Protein is a Potential Therapeutic Target in Alzheimer’s Disease
Current Drug Discovery Technologies Anti-Viral Agents in Neurodegenerative Disorders: New Paradigm for Targeting Alzheimer’s Disease
Recent Patents on Anti-Infective Drug Discovery Vanutide Cridificar and the QS-21 Adjuvant in Japanese Subjects with Mild to Moderate Alzheimer’ s Disease: Results from Two Phase 2 Studies
Current Alzheimer Research Quantitative and Mechanistic Studies of Aβ Immunotherapy
CNS & Neurological Disorders - Drug Targets Disease Modifying Approaches for Alzheimers Pathology
Current Pharmaceutical Design Peripheral Immune Signatures in Alzheimer Disease
Current Alzheimer Research Alternative Aβ Immunotherapy Approaches for Alzheimers Disease
CNS & Neurological Disorders - Drug Targets Severe Adenovirus Pneumonia Followed by Bacterial Septicaemia: Relevance of Co-Infections in Allogeneic Hematopoietic Stem Cell Transplantation
Infectious Disorders - Drug Targets Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer’s Disease: A New Approach to Therapy
CNS & Neurological Disorders - Drug Targets Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review
Letters in Drug Design & Discovery