Abstract
The suicidal death of erythrocytes should be considered a possible cause of hemolysis and plasma bilirubin overload when there is no evidence of an immune-mediated hemolytic anemia, no consumptive red blood cell disorder, no morphologic or laboratory data to suggest a problem of the red cell membrane, and no evidence of a quantitative or qualitative defect in hemoglobin synthesis.
In neonatal period, xenobiotics, cytokines, osmotic shock, energy depletion, oxidative stress, and variation of temperature may induce an alteration of balance between damaging and protecting factors which can be followed by red cell death. The intraerythrocyte redox balance plays a pivotal role in orchestrating the complex molecular mechanisms leading to eryptosis.
Neonatal erythrocytes are a target of extracellular free radicals and, at the same time, are themselves generators of free radicals through the Fenton reaction.
This review clarifies the complex mechanisms underlying the susceptibility of neonatal erythrocytes to increased oxidative stress.
Keywords: Haemolysis, red blood cells, eryptosis, newborn infants, oxidative stress, erythrocytes.
Current Pediatric Reviews
Title:Mechanisms Involved in the Increased Hemolysis in the Fetus and Newborn
Volume: 13 Issue: 3
Author(s): Bracci Rodolfo, Perrone Serafina and Buonocore Giuseppe*
Affiliation:
- Department of Molecular and Developmental Medicine, University of Siena, viale Bracci 36, CAP 53100,Italy
Keywords: Haemolysis, red blood cells, eryptosis, newborn infants, oxidative stress, erythrocytes.
Abstract: The suicidal death of erythrocytes should be considered a possible cause of hemolysis and plasma bilirubin overload when there is no evidence of an immune-mediated hemolytic anemia, no consumptive red blood cell disorder, no morphologic or laboratory data to suggest a problem of the red cell membrane, and no evidence of a quantitative or qualitative defect in hemoglobin synthesis.
In neonatal period, xenobiotics, cytokines, osmotic shock, energy depletion, oxidative stress, and variation of temperature may induce an alteration of balance between damaging and protecting factors which can be followed by red cell death. The intraerythrocyte redox balance plays a pivotal role in orchestrating the complex molecular mechanisms leading to eryptosis.
Neonatal erythrocytes are a target of extracellular free radicals and, at the same time, are themselves generators of free radicals through the Fenton reaction.
This review clarifies the complex mechanisms underlying the susceptibility of neonatal erythrocytes to increased oxidative stress.
Export Options
About this article
Cite this article as:
Rodolfo Bracci , Serafina Perrone and Giuseppe Buonocore *, Mechanisms Involved in the Increased Hemolysis in the Fetus and Newborn, Current Pediatric Reviews 2017; 13 (3) . https://dx.doi.org/10.2174/1573396313666170718151248
DOI https://dx.doi.org/10.2174/1573396313666170718151248 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Ligands and Therapeutic Perspectives of Adenosine A2A Receptors
Current Pharmaceutical Design Neglected Diseases Caused By Bacterial Infections
Current Medicinal Chemistry Analgesic Potential of TRPV3 Antagonists
Current Topics in Medicinal Chemistry Editorial
Reviews on Recent Clinical Trials Cachexia and Oxidative Stress in Cancer: An Innovative Therapeutic Management
Current Pharmaceutical Design Fibrates and Microvascular Complications in Diabetes - Insight from the FIELD Study
Current Pharmaceutical Design Vascular Endothelial Growth Factor (VEGF) Biochemistry and Development of Inhibitory Drugs
Current Drug Therapy Central Oxytocinergic Neurotransmission: A Drug Target for the Therapy of Psychogenic Erectile Dysfunction
Current Drug Targets Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs
Recent Patents on Cardiovascular Drug Discovery The Metabolism of Diclofenac - Enzymology and Toxicology Perspectives
Current Drug Metabolism Redox-Sensitive Smart Nanosystems for Drug and Gene Delivery
Current Organic Chemistry Pathogenesis of HIV-Associated Non-Hodgkin Lymphoma
Current HIV Research Anti-Inflammatory Responses of Resveratrol
Inflammation & Allergy - Drug Targets (Discontinued) Editorial [Hot Topic: Anti-Inflammatory Therapy (Guest Editor: Dr. Subhash P. Khanapure)]
Current Topics in Medicinal Chemistry Bestatin as an Experimental Tool in Mammals
Current Drug Metabolism Sepsis-induced Cardiomyopathy
Current Cardiology Reviews Melatonin and Synthetic Melatoninergic Agonists in Psychiatric and Age-associated Disorders: Successful and Unsuccessful Approaches
Current Pharmaceutical Design Five-Lipoxygenase Pathway of Arachidonic Acid Metabolism in Carcinogenesis and Cancer Chemoprevention
Current Cancer Drug Targets Influence of H2O2 Formed In Situ on the Photodegradation of Ibuprofen and Ketoprofen
Current Physical Chemistry Fluoxetine and all other SSRIs are 5-HT<sub>2B</sub> Agonists - Importance for their Therapeutic Effects
Current Neuropharmacology