Metabolic Syndrome, Dyslipidemia and Regulation of Lipoprotein Metabolism

Title:Metabolic Syndrome, Dyslipidemia and Regulation of Lipoprotein Metabolism

Volume: 14 Issue: 5

Author(s): Jahangir Iqbal*, Ali Al Qarni, Abbas Hawwari, Ahmad F. Alghanem and Gasmelseed Ahmed

Affiliation:

• King Abdullah International Medical Research Center, MNGHA, Al Ahsa, 31982,Saudi Arabia

Keywords: Metabolic syndrome, dyslipidemia, insulin resistance, lipid metabolism, lipoprotein biosynthesis, microRNA.

Abstract: Background: Metabolic syndrome is associated with increased risk for both type 2 diabetes and cardiovascular disease. Development of these pathologies is associated with the disorders of lipid and lipoprotein metabolism. Dyslipidemia leads to the overproduction of potentially atherogenic lipid and lipoproteins. Furthermore, there is a decrease in the levels of high-density lipoproteins and an increase in the levels of remnant and small dense LDL particles.

Conclusion: In the current review, we have discussed the pathophysiology of lipoprotein biosynthesis and metabolism in the metabolic syndrome. Finally, we describe regulation of lipoprotein metabolism which may be used as a potential target for treating dyslipidemia in metabolic syndrome.

Cite this article as:

Iqbal Jahangir *, Al Qarni Ali , Hawwari Abbas , Alghanem F. Ahmad and Ahmed Gasmelseed , Metabolic Syndrome, Dyslipidemia and Regulation of Lipoprotein Metabolism, Current Diabetes Reviews 2018; 14(5) . https://dx.doi.org/10.2174/1573399813666170705161039