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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

High Resolution Magic Angle Spinning NMR for Analyzing Small Molecules Attached to Solid Support

Author(s): Harald Schroder

Volume 6, Issue 7, 2003

Page: [741 - 753] Pages: 13

DOI: 10.2174/138620703771981269

Price: $65

Abstract

Solid phase synthesis has become a routine technique in combinatorial chemistry. The need in analytical methods to characterize nondestructively resin bound molecules has been fulfilled by the introduction of High Resolution Magic Angle Spinning (HR MAS) NMR of solvent swollen beads. HR MAS NMR can give solution like proton NMR spectra and one- and two-dimensional NMR techniques are amenable, allowing detailed structure analysis. Recent developments are the application of a diffusion filter to suppress solvent signals and dipolar recoupling techniques to gain spatial information. HR MAS NMR has been applied to monitor reactions and elucidate reaction products.

Keywords: high resolution magic angle spinning nmr, hr mas nmr, diffusion filter, dipolar recoupling, combinatorial chemistry, reaction monitoring on bead


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