Abstract
Background: Research on Chromogranin A (CGA) and its derived fragments convincingly demonstrated the multifunctional activity of the 21 amino acid peptide named Catestatin (CST: human CGA352-372, bovine CGA344-364, rat CGA367-387). This review aims to provide a synopsis of the current information concerning the biological role of CST in health and disease.
Methods: Structured search of bibliographic databases for peer-reviewed research literature.
Results: CST is mainly known as an inhibitor of the nicotinic-dependent Catecholamine (CA) release, and an anti-hypertensive peptide, but its role includes a modulation of antioxidant and immune defense, epidermal function, and adipose tissue homeostasis. CST influences the cardiocirculatory system acting both indirectly, via the autonomic nervous system, and directly by influencing the basal cardiac function, and the stretch-dependent myocardial performance. It also counteracts the effects of adrenergic stimulation on the heart and protects the myocardium from ischemia/reperfusion (I/R) injury, acting in pre- and postconditioning protection.
Conclusions: The knowledge on CST is constantly expanding, thanks to a growing number of human studies that document its involvement in physiological modulation and in many severe diseases, also revealing its applicative potential as a clinical biomarker.
Keywords: Chromogranin A, Catestatin, myocardial performance, cardioprotection, signal transduction, biological role, antimicrobial peptide, innate immunity, adipose, epidermal function, gut diseases.
Current Medicinal Chemistry
Title:Biological Roles of the Eclectic Chromogranin-A-derived Peptide Catestatin
Volume: 24 Issue: 31
Author(s): Teresa Pasqua*, Tommaso Angelone*, Angela Spena and Maria Carmela Cerra
Affiliation:
- Lab of Cardiovascular Physiology, Dept of Biology, Ecology and Earth Sciences, University of Calabria, 87036, Arcavacata di Rende (CS),Italy
- Lab of Cardiovascular Physiology, Dept of Biology, Ecology and Earth Sciences, University of Calabria, 87036, Arcavacata di Rende (CS),Italy
Keywords: Chromogranin A, Catestatin, myocardial performance, cardioprotection, signal transduction, biological role, antimicrobial peptide, innate immunity, adipose, epidermal function, gut diseases.
Abstract: Background: Research on Chromogranin A (CGA) and its derived fragments convincingly demonstrated the multifunctional activity of the 21 amino acid peptide named Catestatin (CST: human CGA352-372, bovine CGA344-364, rat CGA367-387). This review aims to provide a synopsis of the current information concerning the biological role of CST in health and disease.
Methods: Structured search of bibliographic databases for peer-reviewed research literature.
Results: CST is mainly known as an inhibitor of the nicotinic-dependent Catecholamine (CA) release, and an anti-hypertensive peptide, but its role includes a modulation of antioxidant and immune defense, epidermal function, and adipose tissue homeostasis. CST influences the cardiocirculatory system acting both indirectly, via the autonomic nervous system, and directly by influencing the basal cardiac function, and the stretch-dependent myocardial performance. It also counteracts the effects of adrenergic stimulation on the heart and protects the myocardium from ischemia/reperfusion (I/R) injury, acting in pre- and postconditioning protection.
Conclusions: The knowledge on CST is constantly expanding, thanks to a growing number of human studies that document its involvement in physiological modulation and in many severe diseases, also revealing its applicative potential as a clinical biomarker.
Export Options
About this article
Cite this article as:
Pasqua Teresa*, Angelone Tommaso*, Spena Angela and Cerra Carmela Maria, Biological Roles of the Eclectic Chromogranin-A-derived Peptide Catestatin, Current Medicinal Chemistry 2017; 24 (31) . https://dx.doi.org/10.2174/0929867324666170616104759
DOI https://dx.doi.org/10.2174/0929867324666170616104759 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Clinical Significance of the Sympathetic Nervous System in the Development and Progression of Pulmonary Arterial Hypertension
Current Neurovascular Research Targeting JAK/STAT Signaling Pathway in Inflammatory Diseases
Current Signal Transduction Therapy Gene Polymorphism of Angiotensin II Type 1 and Type 2 Receptors
Current Pharmaceutical Design Enzalutamide: A Novel Anti-androgen with Prolonged Survival Rate in CRPC Patients
Mini-Reviews in Medicinal Chemistry Clinically Relevant Drug Interactions with Anti-Alzheimer's Drugs
CNS & Neurological Disorders - Drug Targets Memantine: Its Role in Vascular Dementia
Drug Design Reviews - Online (Discontinued) Blockade of the Renin-Angiotensin-Aldosterone System: Effects on Hypertensive Target Organ Damage
Cardiovascular & Hematological Agents in Medicinal Chemistry Corticosteroid as an Adjunct in the Treatment of Endobronchial Tuberculosis: A Systematic Review & Meta-analysis
Current Pediatric Reviews Omega-3 Fatty Acids for Nutrition and Medicine: Considering Microalgae Oil as a Vegetarian Source of EPA and DHA
Current Diabetes Reviews Drugs for the Treatment of Hypercholesterolemia and their Benefits Beyond Cholesterol Lowering to Prevent Vascular Disease
Vascular Disease Prevention (Discontinued) The Role of Inflammatory Biomarkers in the Detection and Therapy of Atherosclerotic Disease
Current Vascular Pharmacology Developments in Imaging Technologies Related to Hypertensive Cardiovascular Diseases
Current Pharmaceutical Design Alterations in Plasma Triglyceride Concentrations Following Two Oral Meals with Different Fat Content in Patients with Type 2 Diabetes Mellitus
Current Vascular Pharmacology Development of New Therapeutic Agents for Fibrodysplasia Ossificans Progressiva.
Current Molecular Medicine One Special Question to Start with: Can HIF/NFkB be a Target in Inflammation?
Endocrine, Metabolic & Immune Disorders - Drug Targets Lipoprotein(a): Current Perspectives
Current Vascular Pharmacology Tyrosine Kinase Inhibitors
Current Cancer Drug Targets Patent Selections
Recent Patents on Cardiovascular Drug Discovery Editorial (Hot Topic: Update on Treatment Strategies in Patients with Non-alcoholic Fatty Liver Disease)
Current Pharmaceutical Design MicroRNAs and the Warburg Effect: New Players in an Old Arena
Current Gene Therapy