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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Sulfur – Containing Amino Acids in Seizures: Current State of the Art

Author(s): Dragan Hrncic, Aleksandra Rasic-Markovic, Duro Macut, Dusan Mladenovic, Veselinka Susic, Dragan Djuric and Olivera Stanojlovic*

Volume 25 , Issue 3 , 2018

Page: [378 - 390] Pages: 13

DOI: 10.2174/0929867324666170609090613

Price: $65


Background: Homocysteine and taurine are non-proteinogenic sulfur-containing amino acids with numerous important physiological roles. Homocysteine and taurine are considered to be neurotransmitters and neuromodulators, the first showing clear hyperexcitability role, while the second is known by its inhibitory and neuroprotective properties.

Objective: In this article we addressed the role of homocysteine and its related metabolite homocysteine thiolactone in the development of seizures, focusing on its experimental models in vivo, potential mechanisms of proepileptogenic activity via interactions with glutamatergic neurotransmission, sodium pump activity, oxidative stress, cholinergic system and NO-mediated neuronal signaling, as well as the pharmacological and non-pharmacological approaches to modulate its proconvulsive activity. Additionally, herein we will focus on taurine neuroprotective effects linked with its anticonvulsive properties and mediated by taurine interactions with GABA-ergic and glutamatergic system and oxidative stress.

Keywords: Homocysteine, taurine, amino acids, sulfur, seizures, epilepsy, oxidative stress, glutamate.

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