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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Electrochemical Detectors in Liquid Chromatography: Recent Trends in Pharmaceutical and Biomedical Analysis

Author(s): Jean-Michel Kauffmann*, Nurgul K. Bakirhan, Burcin Bozal-Palabiyik, Bengi Uslu, Rocio Rodriguez Gomez, Marie Vandeput and Sibel A. Ozkan

Volume 25 , Issue 33 , 2018

Page: [4050 - 4065] Pages: 16

DOI: 10.2174/0929867324666170609074826

Price: $65

Abstract

Liquid chromatography (LC) coupled to an electrochemical (EC) detector is a complementary analytical tool compared to LC coupled with optical or mass spectrometry detectors (LC-MS). LC-EC can be applied to the determination of molecules difficult to be analyzed by other commercially available detectors. New EC detector design and new working electrode material have extended the scope of application in the field of pharmaceutical compounds analysis. Combining EC with LC-MS offers additional advantages compared to optical detectors in terms of drug stability and drug metabolism mimicry studies. Selected literature devoted to pharmacologically active compounds in their dosage forms, herbal drugs in natural products, drug residues in feed and/or in biological samples are reported in this review.

Keywords: Liquid chromatography, electrochemical detector, biomedical, pharmaceutical analysis, bioanalysis, amperometry.


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