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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Biosensors for Screening Kinase Inhibitors

Author(s): Nikhil Bhalla* and Pedro Estrela

Volume 17, Issue 22, 2017

Page: [2470 - 2481] Pages: 12

DOI: 10.2174/1568026617666170531113233

Price: $65


For successful drug discovery it is important to understand the fundamentals of the underlying causes and consequences of the diseases for which the drug is being developed. One such physiological process in eukaryotic cells is protein phosphorylation, which is the main post-translational modification of proteins responsible for the onset or progression of Alzheimer's disease, diabetes and various cancers. Protein phosphorylation is facilitated by kinases and inhibitors of kinases act as drugs in controlling or curing these diseases by reducing protein phosphorylation. This review discusses the technologies capable of detecting kinase activity and screening candidate compounds to identify novel inhibitors of protein kinases.

Keywords: Biosensors, Screening Kinase Inhibitors, protein phosphorylation, cancer, drug discovery.

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