摘要
背景:人类过度暴露于太阳紫外线辐射(uvr)仍然是一个主要的公共卫生问题,皮肤癌发病率逐年上升。主要的保护措施是使用合成的紫外线滤光片制成防晒霜,但是越来越多的人担心这些化学物质会对脆弱的海洋生态系统造成损害。另一种选择是使用生物相容性真菌类氨基酸(MAA),这种氨基酸自然存在于各种海洋物种中。它们在自然界中的作用主要被认为是光防护。然而,他们在人类光防护方面的潜力在很大程度上还未被研究。 目的:综述甲基丙烯酸甲酯(MAA)在自然界中的作用,并评价其作为天然防晒剂在人体皮肤光防护中的应用潜力。 方法:对相关文献进行文献综述。 结论:甲基丙烯酸甲酯(MAA)是一种天然的可光性化合物,对海洋生物具有光防护作用。最初认为MAA是基于其在太阳紫外线光谱中的吸收特性而起到保护作用的,很明显MAA是一种多功能的光保护化合物,起到化学和生物抗氧化剂的作用。这表明MAA可能为人类皮肤光防护提供一种新的环保方法。大多数研究都是在体外进行的,目前的数据强烈表明,MAA作为天然生物相容性防晒剂具有开发潜力,能够抵御各种太阳紫外线辐射对人体健康的不利影响。
关键词: 光防护,支原体类氨基酸,皮肤,天然产物,机制,太阳辐射
Current Medicinal Chemistry
Title:Mycosporine-Like Amino Acids for Skin Photoprotection
Volume: 25 Issue: 40
关键词: 光防护,支原体类氨基酸,皮肤,天然产物,机制,太阳辐射
摘要: Background: Excessive human exposure to solar ultraviolet radiation (UVR) continues to be a major public health concern, with skin cancer rates increasing year on year. The major protective measure is the use of synthetic UVR filters formulated into sunscreens, but there is a growing concern that some of these chemicals cause damage to delicate marine ecosystems. One alternative is the use of biocompatible mycosporine-like amino acids (MAA), which occur naturally in a wide range of marine species. Their role within nature is mainly thought to be photoprotective. However, their potential for human photoprotection is largely understudied.
Objective: To review the role of MAA in nature and assess their potential as natural sunscreens for human skin photoprotection.
Method: A literature review of all relevant papers was conducted.
Conclusion: MAA are natural photostable compounds that are thought to offer photoprotection to marine species. Initially thought of as protective based on their absorption properties in the solar UVR spectrum, it is clear that MAA are multifunctional photoprotective compounds acting as chemical and biological anti-oxidants. This suggests that MAA may offer a novel eco-friendly approach to human skin photoprotection. Most studies have been carried out in vitro and current data strongly suggest that MAA have potential for development as natural biocompatible sunscreens that protect against a diverse range of solar UVR induced adverse effects on human health.
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Cite this article as:
Mycosporine-Like Amino Acids for Skin Photoprotection, Current Medicinal Chemistry 2018; 25 (40) . https://dx.doi.org/10.2174/0929867324666170529124237
DOI https://dx.doi.org/10.2174/0929867324666170529124237 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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