Nanovesicular Formulations for Cancer Gene Therapy

Title:Nanovesicular Formulations for Cancer Gene Therapy

Volume: 23 Issue: 35

Author(s): Lorena Tavano, Elisabetta Mazzotta and Rita Muzzalupo*

Affiliation:

• Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, Ed. Polifunzionale, 87036 Arcavacata di Rende,Italy

Keywords: Liposomes, niosomes, gene therapy, cancer, liposomes, cationic nanocarriers.

Abstract: In the last decades, gene therapy has become a novel therapeutic strategy for cancer treatment, including immunologic and molecular approaches. Among molecular avenue, the design of efficient and effective gene delivery systems, like cationic liposomes and niosomes, has been widely investigated and proposed as the most promising research area. The advantages of cationic vesicles rely on their natural ability to form complexes with anionic genetic molecules and deliver them into the cells via the endosomal pathway. Obviously, cationic vesicles- mediated gene delivery is affected by numerous factors, in particular composition, that strongly affects vesicle physical-chemistry characteristics and transfection effectiveness. This review will analyse the potential of cationic nanocarriers in cancer gene therapy, focusing on the role of liposomes and niosomes as vesicular devices and giving an exhaustive collection of the most representative investigations.

Cite this article as:

Tavano Lorena, Mazzotta Elisabetta and Muzzalupo Rita *, Nanovesicular Formulations for Cancer Gene Therapy, Current Pharmaceutical Design 2017; 23 (35) . https://dx.doi.org/10.2174/1381612823666170519115023