Abstract
Background: Thioureas are widely used as intermediates in organic synthesis, and they are commonly used in several classes of heterocycles.
Objective: There has been an escalating interest in the development of heterocycles employing thioureas as building blocks. Furthermore, thioureas can be utilized as a reagent in a synthesis of a large number of therapeutic agents. In addition, substituted thioureas have recently gained much interest in the preparation of a wide variety of biologically active compounds.
Conclusion: This review highlights the status of thiourea scaffolds in the drug development and heterocyclic synthesis described in the literature mainly since 2010.
Keywords: Thiourea, heterocyclic synthesis, building blocks, drug design, pharmacological effects, multicomponent reactions.
Graphical Abstract
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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