Engineered Bone Tissue with Naturally-Derived Small Molecules

Title:Engineered Bone Tissue with Naturally-Derived Small Molecules

Volume: 23 Issue: 24

Author(s): Guleid Awale, Edgar Wong, Komal Rajpura and Kevin W.-H. Lo*

Affiliation:

• Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine, Farmington, CT 06030,United States

Keywords: Natural products, small molecules, regenerative engineering, musculoskeletal tissue, bone regeneration, drug delivery.

Abstract: Natural products remain the best resources of drugs and drug leads. Recently, there is growing recognition that identifying new small molecules to promote bone regeneration is a laudable translational goal. In fact, new approaches for bone repair and regeneration that involve inexpensive naturally-derived compounds would have an important impact on the treatment of bone disorders and injuries. Over the past several decades, a number of naturally-derived small molecules with the potential of regenerating bone tissue (i.e. osteoinductive) have been reported in the literature. Here, we review the current literature, paying attention to the prospects for natural small molecule-based bone regenerative engineering. We also review various delivery strategies of the selected naturally- derived small molecules for bone regenerative engineering applications.

Cite this article as:

Awale Guleid , Wong Edgar , Rajpura Komal and W.-H. Lo Kevin*, Engineered Bone Tissue with Naturally-Derived Small Molecules, Current Pharmaceutical Design 2017; 23 (24) . https://dx.doi.org/10.2174/1381612823666170516145800