Progress of Trifluoroacetoacetate in the Synthesis of Agrochemicals and Medicines with Fluorine

Title:Progress of Trifluoroacetoacetate in the Synthesis of Agrochemicals and Medicines with Fluorine

Volume: 14 Issue: 5

Author(s): Yuechao Wu , Yulin Wang *, Mingping He , Xiaohong Tao , Jianguang Li , Danping Shan and Liang Lv *

Affiliation:

• College of Chemical and Materials Engineering, 78 Jiu Hua Bei Da Dao, Quzhou City, Zhejiang Province, 324000, Quzhou University,China

• College of Chemical and Materials Engineering, 78 Jiu Hua Bei Da Dao, Quzhou City, Zhejiang Province, 324000, Quzhou University,China

Keywords: Trifluoroacetoacetate, Ethyl 4, 4, 4-trifluoroacetoacetate, trifluoromethyl, agrochemicals, fluorine heterocyclic compound.

Abstract: Fluorinated medicines have become research emphasis in the fields of pesticides and medicines due to their advanced properties. Trifluoroacetoacetate (TFAAE) is an important intermediate for the synthesis of pesticide, medicine and other fluorine compounds. As a useful building block containing trifluoromethyl, TFAAE is widely used in the synthesis of heterocyclic drugs, insecticides and herbicides. In this paper, the preparation methods of TFAAE and the advanced applications in agrochemicals and medicines with fluorine are introduced in detail

Cite this article as:

Wu Yuechao , Wang Yulin *, He Mingping , Tao Xiaohong , Li Jianguang , Shan Danping and Lv Liang *, Progress of Trifluoroacetoacetate in the Synthesis of Agrochemicals and Medicines with Fluorine, Mini-Reviews in Organic Chemistry 2017; 14 (5) . https://dx.doi.org/10.2174/1570193X14666170511122820