Abstract
Background: Diabetes mellitus is the main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is a natural compound isolated from sea urchins and possesses many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments.
Objective: In our study, we tried to collect all the possible hypoglycemic mechanism of echinochrome.
Conclusion: The hypoglycemic effect of echinochrome involving four main pathways; regeneration of pancreas, decrease insulin resistant, increase insulin production and improve glucose homeostasis.
Keywords: Echinochrome, diabetes, acetylcholine, insulin resistance, oxidative stress, hypoglycemic mechanisms.
Current Diabetes Reviews
Title:The Possible Hypoglycemic Mechanisms of Echinochrome
Volume: 14 Issue: 4
Author(s): Ayman Saber Mohamed*, Amel Mahmoud Soliman and Mohamed-Assem Said Marie
Affiliation:
- Zoology Department, Faculty of Science, Cairo University, 12613, Giza,Egypt
Keywords: Echinochrome, diabetes, acetylcholine, insulin resistance, oxidative stress, hypoglycemic mechanisms.
Abstract: Background: Diabetes mellitus is the main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is a natural compound isolated from sea urchins and possesses many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments.
Objective: In our study, we tried to collect all the possible hypoglycemic mechanism of echinochrome.
Conclusion: The hypoglycemic effect of echinochrome involving four main pathways; regeneration of pancreas, decrease insulin resistant, increase insulin production and improve glucose homeostasis.
Export Options
About this article
Cite this article as:
Mohamed Saber Ayman *, Soliman Mahmoud Amel and Marie Said Mohamed-Assem , The Possible Hypoglycemic Mechanisms of Echinochrome, Current Diabetes Reviews 2018; 14 (4) . https://dx.doi.org/10.2174/1573399813666170505120119
DOI https://dx.doi.org/10.2174/1573399813666170505120119 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
Call for Papers in Thematic Issues
Advancing Diabetic Wound Healing: Mechanisms and Interventions
In recent years, diabetic wounds have become a global health concern with the increase in the incidence of diabetes. Diabetic wounds are a kind of chronic and refractory ulcer. It is generally due to the microcirculatory disturbances and the reduced levels of endogenous growth factors. Delayed cutaneous wound healing is ...read more
Oxidative and inflammatory responses in the development of secondary diabetic complications
Diabetes, along with its associated secondary complications, represents a significant global health challenge, contributing significantly to morbidity and mortality. Unhealthy lifestyle habits, reduced physical activity, environmental pollutants, and stress are pivotal factors in the onset of diabetes, particularly type-2 diabetes. Poorly managed hyperglycemia can lead to various complications, including neuropathy, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Effects of Antihypertensive Therapy on Haemostatic Parameters
Current Pharmaceutical Design Nopal (Opuntia spp.) and its Effects on Metabolic Syndrome: New Insights for the Use of a Millenary Plant
Current Pharmaceutical Design Upregulated Retinol Binding Protein and Transthyretin as Predictive Biomarkers of Gestational Diabetes Mellitus
Current Proteomics Sestrins: A New Kid for Stroke Treatment?
Current Drug Delivery <i>Delonix regia</i> a Folklore Remedy for Diabetes; Attenuates Oxidative Stress and Modulates Type II Diabetes Mellitus
Current Pharmaceutical Biotechnology EDITORIAL (Thematic issue: Treatment and Diagnosis of Diabetes Mellitus and Its Complication: Advanced Approaches)
Mini-Reviews in Medicinal Chemistry Midkine: A Promising Molecule for Drug Development to Treat Diseases of the Central Nervous System
Current Pharmaceutical Design Teratogenic Potential of Atypical Antipsychotic Drugs, Quetiapine and Aripiprazole in Rats
Current Psychopharmacology Inflammation, Endothelial Dysfunction and Arterial Stiffness as Therapeutic Targets in Cardiovascular Medicine
Current Pharmaceutical Design A Review on Molecular Mechanism of Flavonoids as Antidiabetic Agents
Mini-Reviews in Medicinal Chemistry Targeting the Toll-System in Cardiovascular Sciences
Recent Patents on Inflammation & Allergy Drug Discovery The Burden of Metabolic Diseases Amongst HIV Positive Patients on HAART Attending the Johannesburg Hospital
Current HIV Research Aldose Reductase Enzyme and its Implication to Major Health Problems of the 21st Century
Current Medicinal Chemistry Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors
Current Medicinal Chemistry In Vitro Infection of Human Monocyte-Derived Dendritic Cells with Candida albicans: Receptorial Involvement and Therapeutic Implications
Current Pharmaceutical Design Aliskiren, a Direct Renin Inhibitor, in Clinical Practice: A New Approach in the Treatment of Hypertension
Current Vascular Pharmacology Potent Chemopreventive Agents Against Pancreatic Cancer
Current Cancer Drug Targets Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: A Systematic Review
Current Cardiology Reviews Unravelling the Antioxidant Potential, Alpha-Glucosidase Inhibitory Activity and Phenolic Composition of Dendrocalamus strictus Plantations Generated Biomass Waste (Leaves)
The Natural Products Journal Possible Hypoxia Signaling Induced Alteration of Glucose Homeostasis in Rats Exposed to Chronic Intermittent Hypoxia - Role of Antioxidant (Vitamin C) and Ca2+ Channel Blocker (Cilnidipine)
Current Signal Transduction Therapy