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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Tungsten or Wolfram: Friend or Foe?

Author(s): Maria A. Zoroddu*, Serenella Medici, Massimiliano Peana, Valeria M. Nurchi, Joanna I. Lachowicz, Freda Laulicht-Glickc and Max Costa*

Volume 25, Issue 1, 2018

Page: [65 - 74] Pages: 10

DOI: 10.2174/0929867324666170428105603

Price: $65

Abstract

Tungsten or wolfram was regarded for many years as an enemy within the tin smelting and mining industry, because it conferred impurity or dirtiness in tin mining. However, later it was considered an amazing metal for its strength and flexibility, together with its diamond like hardness and its melting point which is the highest of any metal. It was first believed to be relatively inert and an only slightly toxic metal. Since early 2000, the risk exerted by tungsten alloys, its dusts and particulates to induce cancer and several other adverse effects in animals as well as humans has been highlighted from in vitro and in vivo experiments. Thus, it becomes necessary to take a careful look at all the most recent data reported in the scientific literature, covering the years 2001-2016. In fact, the findings indicate that much more attention should be devoted to thoroughly investigate the toxic effects of tungsten and the involved mechanisms of tungsten metal or tungsten metal ions.

Keywords: Tungsten, toxicity, biological role, carcinogenesis, leukemia, environment, pollution, weapon.


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