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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Research Article

Ultrasound Assisted Synthesis of Quinoline Derivatives in the Presence of SnCl2·2H2O as a Precatalyst in Water: Evaluation of their Antibacterial Activities

Author(s): A.S.G. Prasad, T. Bhaskara Rao, D. Rambabu, Mandava V. Basaveswara Rao* and Manojit Pal*

Volume 18 , Issue 10 , 2018

Page: [895 - 903] Pages: 9

DOI: 10.2174/1389557517666170412112619

Price: $65


Background: SnCl2·2H2O has been used as a convenient precatalyst for the one-pot and rapid synthesis of 2-substituted quinolines under ultrasound irradiation in water. The reaction involved a 3-component reaction of aniline, aldehydes, and ethyl 3,3-diethoxypropionate in the presence of aerial oxygen to give the desired products in good yields.

Conclusion: Several of these compounds showed antibacterial activities when tested against gram-positive and gram-negative species. One compound i.e. 4b showed promising activities across both the species.

Keywords: Antibacterial, MCRs, quinoline, ultrasound, water, SnCl2.

Graphical Abstract

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