Abstract
The formation of senile plaques containing amyloid β peptides (Aβ peptides) as a major constituent plays a significant role in development of Alzheimers disease. The concentration of Aβ peptides in the brain is determined by a combination of their rate of synthesis and their rate of clearance. Considerable effort has been expended in producing inhibitors of the β and γ secretases involved in the synthesis of the Aβ peptides. More recently interest in the mechanism of clearance of the Aβ peptides has emerged, as promoting Aβ peptide clearance represents an alternative therapeutic approach. It now appears that cleavage of Aβ peptide by peptidases and proteases represents the major mechanism of clearance. This review describes those peptidases and proteases implicated in Aβ peptide clearance, the evidence that these enzymes function in vivo, and how they may represent new therapeutic targets.
Keywords: amyloid beta-peptide, ab, a betapeptides, b secretase, r secretase
Current Pharmaceutical Design
Title: Peptidases, Proteases and Amyloid β-Peptide Catabolism
Volume: 9 Issue: 6
Author(s): Louis B. Hersh
Affiliation:
Keywords: amyloid beta-peptide, ab, a betapeptides, b secretase, r secretase
Abstract: The formation of senile plaques containing amyloid β peptides (Aβ peptides) as a major constituent plays a significant role in development of Alzheimers disease. The concentration of Aβ peptides in the brain is determined by a combination of their rate of synthesis and their rate of clearance. Considerable effort has been expended in producing inhibitors of the β and γ secretases involved in the synthesis of the Aβ peptides. More recently interest in the mechanism of clearance of the Aβ peptides has emerged, as promoting Aβ peptide clearance represents an alternative therapeutic approach. It now appears that cleavage of Aβ peptide by peptidases and proteases represents the major mechanism of clearance. This review describes those peptidases and proteases implicated in Aβ peptide clearance, the evidence that these enzymes function in vivo, and how they may represent new therapeutic targets.
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Cite this article as:
Hersh B. Louis, Peptidases, Proteases and Amyloid β-Peptide Catabolism, Current Pharmaceutical Design 2003; 9 (6) . https://dx.doi.org/10.2174/1381612033391676
DOI https://dx.doi.org/10.2174/1381612033391676 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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