Abstract: Background: Iron-sulfur clusters are inorganic prosthetic groups composed of only iron and inorganic sulfur atoms. Organisms develop different pathways to sense their local environment and to respond and adapt to changes.Objective: We focused on Fe-S-containing proteins, which control their activity in response to redox signals by changing the redox state of their cluster. Result: When reduced, these Fe-S cluster-containing sensors are all inactive. As soon as their cluster perceives a signal that induces its oxidation, they switch to an « active state ». Conclusion: This sensing mechanism efficiently helps cells to turn on survival pathways quickly and recover from stressful conditions.
Keywords: Fe-S cluster, sensor, redox state, cellular adaptive response, mitoNEET, iron.