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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Recent Progress in 808 nm Excited Upconversion Nanomaterials as Multifunctional Nanoprobes for Visualized Theranostics in Cancers

Author(s): Leyong Zeng, Di Wu*, Ying Tian, Yuanwei Pan, Aiguo Wu, Jinchao Zhang* and Guangming Lu*

Volume 25 , Issue 25 , 2018

Page: [2954 - 2969] Pages: 16

DOI: 10.2174/0929867324666170320115959

Price: $65


Near-infrared (NIR) light responsive nanomaterials have attracted considerable attention due to their location in the biological window. Especially, lanthanide-doped nanomaterials exhibit unique upconversion luminescence (UCL) properties with low background interference and long luminescence lifetime, which makes them promising in imaging diagnosis of cancers. Compared with traditional upconversion nanomaterials excited by 980 nm laser, 808 nm excitation can overcome the disadvantages of high heating effect and weak penetration depth induced by excitation source. Therefore, developing 808 nm excited upconversion nanoprobes will be important for the in vivo bio-imaging and visualized theranostics of tumors in deep-tissue. In the review paper, we systematically summarized the synthesis strategy and luminescence modulation of Nd3+-sensitized upconversion nanomaterials under 808 nm excitation, discussed the influence of excitation source on heating effect and penetration depth, and particularly focused on their applications in UCL imaging, multi-modal imaging and imaging-guided therapy of cancers.

Keywords: Nd3+-sensitized upconversion nanomaterials, low-heating effect, strong penetration depth, upconversion luminescence imaging, multi-modal imaging, visualized theranostics.

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