Abstract
Background: Cancer is a great threat of human health worldwide due to the uncontrollable spread of malignant cells throughout the body. Accurate diagnosis and targeted therapy approaches are critical factors for cancer treatment. Combination of therapeutic and diagnostic agents in a single nanocarrier enables to simultaneously monitor the cancer progression and tune disease therapy with minimum side effect.
Objective: Carbon dots are a novel class of small fluorescence carbon nanostructures with size less than 10 nm at least in one dimension, which exhibit excellent optical properties, larger surface area to volume ratio and low toxicity. The unique properties of carbon dots make it as an ideal carrier for incorporation of cancer targeting moieties, bio-imaging agents and antineoplastic agents in one delivery system.
Methods: An literature search was conducted using Web of Science to find out articles related to carbon dots and tumor theranostics.
Results: Numerous applications of carbon dots in cancer theranostics have been reported during the past 10 years. This review introduces a brief history and basic fluorescent properties of carbon dots, and then discusses synthesis strategies and applications of carbon dots in biological imaging, targeted anti-cancer drug delivery, photodynamic therapy, photothermal therapy as well as gene delivery for cancer theranostics. Future directions of carbon dots in cancer theranostics are also highlighted.
Keywords: Carbon dots, multicolorful, tumor theranostics, nanocarrier, imaging and drug delivery, cancer.
Current Medicinal Chemistry
Title:Multicolorful Carbon Dots for Tumor Theranostics
Volume: 25 Issue: 25
Author(s): Haitao Wang, Jingran Bi, Bei-Wei Zhu and Mingqian Tan*
Affiliation:
- School of Food Science and Technology, Dalian Polytechnic University, National Engineering Research Center of Seafood, Qinggongyuan 1, Ganjingzi District, Dalian 116034,China
Keywords: Carbon dots, multicolorful, tumor theranostics, nanocarrier, imaging and drug delivery, cancer.
Abstract: Background: Cancer is a great threat of human health worldwide due to the uncontrollable spread of malignant cells throughout the body. Accurate diagnosis and targeted therapy approaches are critical factors for cancer treatment. Combination of therapeutic and diagnostic agents in a single nanocarrier enables to simultaneously monitor the cancer progression and tune disease therapy with minimum side effect.
Objective: Carbon dots are a novel class of small fluorescence carbon nanostructures with size less than 10 nm at least in one dimension, which exhibit excellent optical properties, larger surface area to volume ratio and low toxicity. The unique properties of carbon dots make it as an ideal carrier for incorporation of cancer targeting moieties, bio-imaging agents and antineoplastic agents in one delivery system.
Methods: An literature search was conducted using Web of Science to find out articles related to carbon dots and tumor theranostics.
Results: Numerous applications of carbon dots in cancer theranostics have been reported during the past 10 years. This review introduces a brief history and basic fluorescent properties of carbon dots, and then discusses synthesis strategies and applications of carbon dots in biological imaging, targeted anti-cancer drug delivery, photodynamic therapy, photothermal therapy as well as gene delivery for cancer theranostics. Future directions of carbon dots in cancer theranostics are also highlighted.
Export Options
About this article
Cite this article as:
Wang Haitao , Bi Jingran , Zhu Bei-Wei and Tan Mingqian*, Multicolorful Carbon Dots for Tumor Theranostics, Current Medicinal Chemistry 2018; 25 (25) . https://dx.doi.org/10.2174/0929867324666170316110810
DOI https://dx.doi.org/10.2174/0929867324666170316110810 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Kinases as Targets for Parkinson's Disease: From Genetics to Therapy
CNS & Neurological Disorders - Drug Targets Drugs Interfering with Apoptosis in Breast Cancer
Current Pharmaceutical Design Synthetic Sustained Gene Delivery Systems
Current Topics in Medicinal Chemistry Molecular Architecture of Tumor Suppressor p53
Current Topics in Medicinal Chemistry MicroRNAs - Key Players in Haematopoiesis
Current Signal Transduction Therapy WT1 as a Novel Target Antigen for Cancer Immunotherapy
Current Cancer Drug Targets The Role of a Disturbed Arginine/NO Metabolism in the Onset of Cancer Cachexia: A Working Hypothesis
Current Medicinal Chemistry Combination of DC Vaccine and Conventional Chemotherapeutics
Anti-Cancer Agents in Medicinal Chemistry Modulating Fatty Acid Metabolism and the AMP-Activated Protein Kinase Pathway as a Target for Obesity Therapy
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Therapeutic Application of Natural Medicine Monomers in Cancer Treatment
Current Medicinal Chemistry Bioinspired Nanocomposites: Applications in Disease Diagnosis and Treatment
Pharmaceutical Nanotechnology Histone Deacetylase Inhibitors as Potential Therapeutic Agents for the Treatment of Malignant Mesothelioma
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in Image-Based Stem-Cell Labeling and Tracking, and Scaffold-Based Organ Development in Cardiovascular Disease
Recent Patents on Medical Imaging Integrating the Universe of Effector and Regulatory Immune Cell Subsets: An Emerging Role of Protein-Glycan Interactions
Current Immunology Reviews (Discontinued) New Derivatives of GnRH as Potential Anticancer Therapeutic Agents
Current Medicinal Chemistry The Coronin Family and Human Disease
Current Protein & Peptide Science Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes
Current Medicinal Chemistry Hepatitis C Virus NS3/4A Protease Inhibitors
Recent Patents on Anti-Infective Drug Discovery Recent Advances of Novel Therapeutic Agents from Botanicals for Prevention and Therapy of Breast Cancer: An Updated Review
Current Cancer Therapy Reviews Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines
Current Drug Metabolism