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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

General Research Article

Impact of Joint Involvement on Patients Reported Outcomes in Systemic Lupus Erythematosus

Author(s): Tani Chiara, Carli Linda, Delle Sedie Andrea, Riente Lucrezia, Vagnani Sabrina, Talarico Rosaria, Della Rossa Alessandra, Baldini Chiara, Bombardieri Stefano and Mosca Marta*

Volume 14, Issue 2, 2018

Page: [188 - 192] Pages: 5

DOI: 10.2174/1573397113666170314110022

Price: $65


Objective: Joint involvement is common among patients with systemic lupus erythematosus (SLE). Aim of this work was to evaluate the correlation between the presence of joint involvement and patient-reported pain, perception of disease activity, general health and quality of life.

Methods: Fifty consecutive SLE patients were enrolled in the study. All patients underwent a complete clinical evaluation including a 44-joint count; in addition, an ultrasound evaluation of joint involvement of hands and wrists was performed. The following patients reported outcomes (PROs) were completed: Visual Analog Scales 0-100 mm (VAS) evaluating patients reported pain, patient’s perception of global disease activity and general health (GH) and a validated Italian version of the Health Assessment Questionnaire (HAQ).

Results: Fourteen patients (28%) reported a significant morning stiffness lasting for more than 30 minutes; hand or wrist arthritis was clinically detectable in 10 (20%) patients, while the US evaluation exhibited at least one joint or tendon pathology in 18 patients (36%). The mean VAS score for pain and disease activity perception was 27 (±27.7) mm and 25.3 (±25.2) mm, respectively, the mean of GH score was 33.2 (±24.3) mm, and the mean HAQ score was 0.34 (±0.5). A significant correlation was observed between VAS score for pain, patient’s perception of disease activity and GH and the presence of arthritis.

Conclusion: PROs may play an important role in guiding therapeutic decisions and suggest the utility of ultrasound evaluation in patients reporting articular symptoms.

Keywords: Patient reported outcomes, joint involvement, SLE, burden of disease, therapeutic decisions, ultrasound evaluation.

Graphical Abstract

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