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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

The Role of Stress in Inflammatory Bowel Diseases

Author(s): Dolores Sgambato, Agnese Miranda, Rocco Ranaldo, Alessandro Federico and Marco Romano*

Volume 23, Issue 27, 2017

Page: [3997 - 4002] Pages: 6

DOI: 10.2174/1381612823666170228123357

Price: $65


Background: Inflammatory bowel disease (IBD) is a multi-factorial systemic disorder which involves immune, genetic and environmental factors. Stress, in its various forms, plays an important role in gastrointestinal diseases and, in particular, in IBD.

Methods: Here, we focus on the environmental stressors in different aspects of IBD (pathogenesis, course and severity of disease) and, in particular, will evaluate the mechanisms by which they may influence IBD.

Results: The effect of stress on IBD might be mediated by autonomic nervous system and hypothalamic pituitary adrenal axis. These nervous pathways are part of the so called “brain-gut axis” which links gastrointestinal integrity and functions to central nervous system acting through the increase of intestinal permeability, bacterial translocation and cytokines network.

Conclusion: The incidence of emotional disorders is higher in Crohn's Disease and Ulcerative Colitis compared to general population. Moreover, depression and anxiety influence the course and the severity of the underlying intestinal disease. Hence, it is important to consider appropriate psychological therapy in IBD patients.

Keywords: Gut-brain, inflammatory bowel disease, autonomic nervous system, hypothalamic pituitary adrenal axis, stress, depression, anxiety.

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