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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications

Author(s): Yong Siang Ong, Liqian Gao, Karunakaran A. Kalesh, Zhiqiang Yu*, Jigang Wang, Chengcheng Liu, Yiwen Li, Hongyan Sun* and Su Seong Lee*

Volume 17, Issue 20, 2017

Page: [2302 - 2318] Pages: 17

DOI: 10.2174/1568026617666170224121658

Price: $65

Abstract

Cyclic peptides, owing to their good stability, high resistance to exo- and to some extent endo-peptidases, enhanced binding affinity and selectivity towards target biomolecules, are actively investigated as biochemical tools and therapeutic agents. In this review, we discuss various commonly utilized synthetic strategies for cyclic peptides and peptoids (peptidomimetics), their important screening methods to identify the bioactive cyclic peptides and peptoids such as combinatorial beadbased peptide library, phage display, mRNA display etc. and recent advances in their applications as bioactive compounds. Lastly, we also make a summary and provide an outlook of the research area.

Keywords: Cyclic peptide, Cyclization, Bead-based library, Phage display, mRNA display, Computational.

Graphical Abstract

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