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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Review Article

Nanocarriers Mediated Topical Drug Delivery for Psoriasis Treatment

Author(s): Sevgi Gungor* and Meriem Rezigue

Volume 18 , Issue 5 , 2017

Page: [454 - 468] Pages: 15

DOI: 10.2174/1389200218666170222145240

Price: $65

Sekisui-XenoTech-CDM
Abstract

Background: Psoriasis is a chronic autoimmune inflammatory skin disease affecting 2 to 3% of people worldwide. Topical therapy as first option in the management of psoriasis is an attractive strategy by delivering drugs efficiently into target sites of disease, minimizing systemic side effects of drugs and ensuring high patient compliance. However, the delivery of antipsoriatic agents via conventional topical formulations is limited due to their poor percutaneous penetration and targeting into deeper layers of the skin.

Method: In this review, an overview of skin structure and psoriatic skin as well as different approaches used for the treatment are provided. We discussed the topical nanocarriers including solid lipid nanoparticles, nanostructured lipid carriers, liposomes, niosomes, ethosomes, transfersomes, dendrimers and micelles used to deliver antipsoriatic drugs. We also summarized the 2011 onward research studies dealing with the application of nanocarriers for psoriasis treatment.

Result: In the last decades, numerous types of nanocarriers have been widely investigated as a novel delivery approach to reach effective antipsoriatic drug concentrations. These nanocarriers can enhance the therapeutic efficacy and minimize the toxicity of the drugs by lowering the dose. They also improve drug localization in the skin and achieve site-specific drug targeting. But, most of the available studies have lack of clinical outcome in psoriasis and required more focus on the clinical evaluation.

Conclusion: Nanocarriers could enhance deposition of antipsoriatic drugs in targeted sites of the skin. Nevertheless, still there is a need to develop more effective simulated models that provide realistic model for psoriasis.

Keywords: Nanocarrier, psoriasis, skin delivery, skin targeting, topical delivery, anti-psoriatic drug.

Graphical Abstract

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