摘要
在过去的15年中,我们看到了针对乳腺癌细胞内生物分子靶点的药物开发的巨大扩展。某些受体(ER,PgR,HER-2,VEGF-R)的过度表达以及几种细胞内信号转导途径(PI3K-AKT-mTOR途径,MEK-MAPK途径,PTEN丧失等)的改变...)对疾病复发和进展的可能性有很大影响,影响乳腺癌的自然史。最近,乳腺癌的生物分子分类(Luminal A / B,HER2驱动,Basal Like)最终确定了针对分子靶点的特定治疗方法,以与传统化疗相关或不相关,并用于疾病的预后。在下面的段落中,我们将阐述已经接受乳腺癌适应症的主要靶向药物,包括局部和晚期疾病,指的是特定靶点(激素受体,HER2,VEGF,m-TOR,PARP等)。 ..)。
关键词: 乳腺癌,癌症,靶标,生物分子,受体,治疗,转移
Current Cancer Drug Targets
Title:The Real Impact of Target Therapy in Breast Cancer Patients: Between Hope and Reality
Volume: 18 Issue: 5
关键词: 乳腺癌,癌症,靶标,生物分子,受体,治疗,转移
摘要: Over the last 15 years, we have seen a huge expansion of the development of drugs directed against biomolecular targets within breast cancer cells. The over-expression of certain receptors (ER, PgR, HER-2, VEGF-R), as well as alteration of several intracellular signal transduction pathways (the PI3K-AKT-mTOR pathway, MEK-MAPK pathway, loss of PTEN, etc ...) has a great impact on the likelihood of recurrence and progression of the disease, influencing the natural history of breast cancer. The recent biomolecular classification of breast cancer (Luminal A / B, HER2- driven, Basal Like) allowed finally to identify specific treatments against molecular target to associate or not to traditional chemotherapy, and to use in relation to the prognosis of the disease. In the following paragraphs, we will set out the major targeted drug that have received indications in breast cancer, both in the localized and in advanced disease, referring to the specific target (hormonal receptors, HER2, VEGF, m-TOR, PARP etc ...).
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The Real Impact of Target Therapy in Breast Cancer Patients: Between Hope and Reality, Current Cancer Drug Targets 2018; 18 (5) . https://dx.doi.org/10.2174/1568009617666170209100322
DOI https://dx.doi.org/10.2174/1568009617666170209100322 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
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