Oncolytic Herpes Simplex Virus Vectors Fully Retargeted to Tumor- Associated Antigens

Title:Oncolytic Herpes Simplex Virus Vectors Fully Retargeted to Tumor- Associated Antigens

Volume: 18 Issue: 2

Author(s): Hiroaki Uchida*, Hirofumi Hamada, Kenji Nakano, Heechung Kwon, Hideaki Tahara, Justus B. Cohen and Joseph C. Glorioso

Affiliation:

• Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo,Japan

Keywords: Cancer, gene therapy, herpes simplex virus, oncolytic virus, targeting, vector, virotherapy, virus entry.

Abstract: Oncolytic virotherapy is a novel therapeutic modality for malignant diseases that exploits selective viral replication in cancer cells. Herpes simplex virus (HSV) is a promising agent for oncolytic virotherapy due to its broad cell tropism and the identification of mutations that favor its replication in tumor over normal cells. However, these attenuating mutations also tend to limit the potency of current oncolytic HSV vectors that have entered clinical studies. As an alternative, vector retargeting to novel entry receptors has the potential to achieve tumor specificity at the stage of virus entry, eliminating the need for replication-attenuating mutations. Here, we summarize the molecular mechanism of HSV entry and recent advances in the development of fully retargeted HSV vectors for oncolytic virotherapy. Retargeted HSV vectors offer an attractive platform for the creation of a new generation of oncolytic HSV with improved efficacy and specificity.

Cite this article as:

Uchida Hiroaki*, Hamada Hirofumi, Nakano Kenji, Kwon Heechung, Tahara Hideaki, Cohen B. Justus and Glorioso C. Joseph, Oncolytic Herpes Simplex Virus Vectors Fully Retargeted to Tumor- Associated Antigens, Current Cancer Drug Targets 2018; 18 (2) . https://dx.doi.org/10.2174/1568009617666170206105855