Abstract
Pancreatic cancer remains one of the most lethal cancers worldwide, with an extremely poor prognosis. This cancer is considered the 5th leading cause of cancer related death. The median survival after diagnosis is generally 2-8 months and five-year survival rate is less than 5%. In recent years, nanotechnology is emerging as a rising approach for drug delivery since it has opened up new landscapes in medicine through introduction of smart nanocarrier systems that can selectively deliver the therapeutic agent in a specific region and in appropriate levels, reducing the adverse side effects. This review covers the main delivery systems developed so far for anticancer drug delivery to the pancreas over a period of 20 years, from polymeric to lipidic-based nanosystems, with a particular emphasis on albumin as core material.
Keywords: Pancreatic cancer, nanoparticles, targeted therapy, polymers, drug delivery, signaling pathways.
Current Drug Metabolism
Title:Pancreatic Cancer Therapy Review: From Classic Therapeutic Agents to Modern Nanotechnologies
Volume: 18 Issue: 4
Author(s): Ana Rebelo, Jesus Molpeceres, Patrícia Rijo and Catarina Pinto Reis
Affiliation:
Keywords: Pancreatic cancer, nanoparticles, targeted therapy, polymers, drug delivery, signaling pathways.
Abstract: Pancreatic cancer remains one of the most lethal cancers worldwide, with an extremely poor prognosis. This cancer is considered the 5th leading cause of cancer related death. The median survival after diagnosis is generally 2-8 months and five-year survival rate is less than 5%. In recent years, nanotechnology is emerging as a rising approach for drug delivery since it has opened up new landscapes in medicine through introduction of smart nanocarrier systems that can selectively deliver the therapeutic agent in a specific region and in appropriate levels, reducing the adverse side effects. This review covers the main delivery systems developed so far for anticancer drug delivery to the pancreas over a period of 20 years, from polymeric to lipidic-based nanosystems, with a particular emphasis on albumin as core material.
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Cite this article as:
Rebelo Ana, Molpeceres Jesus, Rijo Patrícia and Reis Pinto Catarina, Pancreatic Cancer Therapy Review: From Classic Therapeutic Agents to Modern Nanotechnologies, Current Drug Metabolism 2017; 18 (4) . https://dx.doi.org/10.2174/1389200218666170201151135
DOI https://dx.doi.org/10.2174/1389200218666170201151135 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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