摘要
普遍应激蛋白在细菌,古细菌,植物和其他真核生物中普遍表达。 USP的一般性质是它们在细菌适应氧化应激,高温,低pH和/或缺氧方面的作用。越来越多的证据表明,这些蛋白有助于细菌病原体适应人类宿主环境,从而促进定植和致病性。在结核分枝杆菌中的USPs已被充分研究,并可能在结核病的潜伏期中起作用。鲍曼不动杆菌表达的USP,单核细胞增生性李斯特菌和鼠伤寒沙门氏菌都参与了体内的存活,而在铜绿假单胞菌和牙龈卟啉单胞菌中表达的USPs参与了生物膜的形成。洋葱伯克霍尔德氏菌复合体和金黄色葡萄球菌表达在宿主细胞或宿主蛋白粘附中起作用的USP。也有越来越多的证据表明USPs也与抗微生物剂结合,并且可能是未来设计新的抗毒力策略的理想候选者。
关键词: 普遍应激蛋白,UspA,潜伏期,缺氧,氧化应激,细菌感染。
Current Medicinal Chemistry
Title:The Role of Universal Stress Proteins in Bacterial Infections
Volume: 24 Issue: 36
关键词: 普遍应激蛋白,UspA,潜伏期,缺氧,氧化应激,细菌感染。
摘要: Universal stress proteins are ubiquitously expressed in bacteria, archaea and plants and other eukaryotes. A general property of USPs is their role in adaptation of bacteria to oxidative stress, high temperature, low pH and/or hypoxia. There is increasing evidence that these proteins facilitate the adaption of bacterial pathogens to the human host environment, thereby facilitating colonisation and pathogenicity. USPs in Mycobacterium tuberculosis are well studied and may play a role in latency of tuberculosis. USP expressed by Acinetobacter baumannii, Listeria monocytogenes and Salmonella enterica serovar Typhimurium are involved in survival in vivo, while USPs expressed in Pseudomonas aeruginosa and Porphyromonas gingivalis are involved in biofilm formation. Burkholderia cepacia complex and Staphylococcus aureus express USPs that play roles in host cell or host protein adhesion. There is also increasing evidence that USPs also bind to antimicrobial agents and may be ideal candidates to target in the future design of new anti-virulence strategies.
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Cite this article as:
The Role of Universal Stress Proteins in Bacterial Infections, Current Medicinal Chemistry 2017; 24 (36) . https://dx.doi.org/10.2174/0929867324666170124145543
DOI https://dx.doi.org/10.2174/0929867324666170124145543 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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