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Current Pediatric Reviews

Editor-in-Chief

ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Review Article

Update on Predicting Severe Hyperbilirubinemia and Bilirubin Neurotoxicity Risks in Neonates

Author(s): Pearl W. Chang*, Thomas B. Newman and M. Jeffrey Maisels

Volume 13, Issue 3, 2017

Page: [181 - 187] Pages: 7

DOI: 10.2174/1573396313666170123151408

Price: $65

Abstract

Extreme hyperbilirubinemia and kernicterus, though rare, continue to occur despite the adoption of universal screening. Unless they are known to have glucose-6-phosphate dehydrogenase deficiency, infants who currently develop kernicterus in high resource countries are often otherwise healthy newborns discharged from the well-baby nursery. In this review, we highlight risk factors that increase the risk of a newborn ≥35 weeks gestational age developing severe hyperbilirubinemia, as well as the risk factors that increase the hyperbilirubinemic infant’s risk of kernicterus.

Keywords: Hyperbilirubinemia, jaundice, neonates, kernicterus, neurotoxicity, phototherapy.


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