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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Research Article

Synaptic Inputs of Neural Afferent Pathways to Vasopressin- and Oxytocin-Secreting Neurons of Supraoptic and Paraventricular Hypothalamic Nuclei

Author(s): Michele Iovino, Vito Angelo Giagulli, Brunella Licchelli, Emanuela Iovino, Edoardo Guastamacchia and ">Vincenzo Triggiani

Volume 16, Issue 4, 2016

Page: [276 - 287] Pages: 12

DOI: 10.2174/1871530317666170104124229

Price: $65


Background: Magnocellular neurosecretory neurons of the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei synthesize vasopressin and oxytocin in response to signals generated by osmoreceptors and baroreceptors and, respectively, by receptors of the nipples and cervix.

Methods: We analyzed the literature identifying relevant articles dealing with synaptic inputs of neural afferent pathways to Vasopressin-and Oxytocin-secreting neurons of SON and PVN.

Results: This article focuses on the multisynaptic pathways involved in the regulation of Vasopressin and Oxytocin secretion.

Conclusion: An updated topographic description of the afferent pathways involved in the regulation of VPergic and OTergic neurons and their synaptic inputs inducing the stimulus-secretion-coupling has been depicted.

Keywords: Circumventricular organs, forebrain and brainstem afferent pathways, nucleus tracti solitarii, oxytocin, supraoptic and paraventricular magnocellular neurons, synaptic inputs, vasopressin.

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