Abstract
Opioid peptides showing selectivity for d receptor have been isolated from enzymatic digests of plant proteins. Five peptides were derived from wheat gluten, and named gluten exorphins A5, A4, B5, B4 and C. Two opioid peptides were also released from spinach ribulosebisphosphate- carboxylase / oxygenase (Rubisco), and named rubiscolins-5 and -6. Among them, gluten exorphin 5A (Gly-Tyr-Tyr-Pro-Thr) and rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) improved learning performance in step-through type passive avoidance test after post-training oral administration in mice at doses of 300 mg / kg and 100 mg / kg, respectively, which are smaller than those required for antinociceptive activity.
Keywords: opioid peptide, gluten exorphin, rubisco, antinociception, learning, memory, anxiolytic, antidepressant
Current Pharmaceutical Design
Title: Delta Opioid Peptides Derived from Plant Proteins
Volume: 9 Issue: 16
Author(s): M. Yoshikawa, M. Takahashi and S. Yang
Affiliation:
Keywords: opioid peptide, gluten exorphin, rubisco, antinociception, learning, memory, anxiolytic, antidepressant
Abstract: Opioid peptides showing selectivity for d receptor have been isolated from enzymatic digests of plant proteins. Five peptides were derived from wheat gluten, and named gluten exorphins A5, A4, B5, B4 and C. Two opioid peptides were also released from spinach ribulosebisphosphate- carboxylase / oxygenase (Rubisco), and named rubiscolins-5 and -6. Among them, gluten exorphin 5A (Gly-Tyr-Tyr-Pro-Thr) and rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) improved learning performance in step-through type passive avoidance test after post-training oral administration in mice at doses of 300 mg / kg and 100 mg / kg, respectively, which are smaller than those required for antinociceptive activity.
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Cite this article as:
Yoshikawa M., Takahashi M. and Yang S., Delta Opioid Peptides Derived from Plant Proteins, Current Pharmaceutical Design 2003; 9 (16) . https://dx.doi.org/10.2174/1381612033454838
DOI https://dx.doi.org/10.2174/1381612033454838 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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